Phylo is an experimental video game about multiple sequence alignment optimisation, where the player arranges representations of nucleotides. The goal of the game is to maximize the matches and minimize the mismatches between the DNA sequences on the digital game board.
For the uninitiated, a sequence alignment is a way of arranging the sequences of DNA, RNA or protein to identify regions of similarity. These similarities may be consequences of functional, structural or evolutionary relationships between the sequences. From such an alignment, biologists may infer shared evolutionary origins, identify functionally important sites, and illustrate mutation events. More importantly, biologists can trace the source of certain genetic diseases.
If you can get past the terminology, then the game is quite simple to understand – it’s about moving coloured blocks to achieve matching colours between rows of colours.